Gut Microbiota in Immuno-Oncology: A Practical Guide for Medical Oncologists With a Focus on Antibiotics Stewardship

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Antibiotics are associated with worse outcomes in lung cancer patients treated with chemotherapy and immunotherapy

Elkrief 2024

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PIO Annual Meeting 2025

16-17 June 2025

Paris, France

The 2025 Paris Immuno-Oncology Conference (PIO) will focus on Tumor Immunology & Immunotherapy and the Microbiota-Immune Interface. Together, we will explore the links between cancer, immunity, and the microbiota, and discuss innovative therapeutic strategies to harness the body’s ecosystem against cancer.

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Impact

COHORTS

2K+

Patients

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Publications

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The Atlas aims to create an overview of clinical cancer immunotherapy cohorts using 3 key data sources:

Clinical Data

Outcome Data

Microbiome Modifier

Extended data sources will also include:

Associated microbiome profiling and/or associated blood/stool samples yet to be analysed (multi-omics)

Granular information on exposure to medication

Lifestyle (Diet and Exercise)

Longitudinal biospecimen and patient data tracking

Building a path to clinical insight through:

Standardised clinical, biospecimen and assay data capturing

Granular information on medication exposure history

Standardised bioinformatic workflows and state-of-the art microbiome profiling

Integrated multi-omic and immunotherapy response data

The challenge

Promising evidence is emerging at the intersection of immuno-oncology and the microbiome, yet the lack of transparent mapping of existing datasets and standardisation creates a substantial barrier for researchers and organisations seeking clinical translation.

The solution

The Seerave Global Oncobiome Atlas catalogs and provides visibility to existing, developing, and planned clinical datasets through a central reference point.

It offers concrete solutions for harmonizing data across different sites and make pathways transparent through which these resources can be accessed. This enables collaboration with the ultimate goal of improving patient outcomes by minimising redundancy and accelerating discovery.

Seerave Global OncoBiome Atlas is a growing catalogue of key clinical datasets at the intersection of immuno-oncology and microbiome science.

The Atlas aims to catalyze investigations and hypothesis-driven evidence-generation around the role of microbiome-modifiers in cancer therapy.

FROM CLINICAL DATA TO INSIGHT

Clinical Cohorts at the Intersection of the Microbiome, Immune System & Cancer Axis

Explore the Atlas